A splicing silencer that regulates smooth muscle specific alternative splicing is active in multiple cell types.
Alternative splicing of alpha-tropomyosin (alpha-TM) involves mutually exclusive selection of exons 2 and 3. Selection of exon 2 in smooth muscle (SM) cells is due to inhibition of exon 3, which requires both binding sites for polypyrimidine tract-binding protein as well as UGC (or CUG) repeat eleme...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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