Placental syncytiotrophoblast-derived extracellular vesicles carry active NEP (neprilysin) and are increased in preeclampsia
NEP (neprilysin) is a widely expressed membrane-bound metalloprotease, which binds and cleaves a variety of peptides including vasodilators, natriuretics, and diuretics. Higher levels of NEP result in hypertension—a cardinal feature of the placental disease preeclampsia. Syncytiotrophoblast-derived...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
American Heart Association
2019
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