IMP/GTP balance modulates cytoophidium assembly and IMPDH activity
Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, plays an important role in cell metabolism and proliferation. It has been demonstrated that IMPDH can aggregate into a macrostructure, termed the cytoophidium, in mammalian cells under a variety of con...
| Główni autorzy: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Język: | English |
| Wydane: |
BioMed Central
2018
|