Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma

Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma

Decysin-1 (ADAMDEC1) is an orphan ADAM-like metalloprotease with unknown biological function and a short domain structure. ADAMDEC1 mRNA has previously been demonstrated primarily in macrophages and mature dendritic cells. Here, we generated monoclonal antibodies (mAbs) against the mature ADAMDEC1 p...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Lund, J, Elimar Bitsch, A, Grønbech Rasch, M, Enoksson, M, Troeberg, L, Nagase, H, Loftager, M, Overgaard, M, Petersen, H
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Taylor and Francis 2017

Những quyển sách tương tự

Evidence for Restricted Reactivity of ADAMDEC1 with Protein Substrates and Endogenous Inhibitors.
Bằng: Lund, J, et al.
Được phát hành: (2015)

ADAMDEC1 accelerates GBM progression via activation of the MMP2-related pathway
Bằng: Huimin Qi, et al.
Được phát hành: (2022-09-01)

ADAMDEC1 promotes the malignant progression of cholangiocarcinoma by regulating NF-κB signaling pathway
Bằng: Shuo Zhou, et al.
Được phát hành: (2025-01-01)

ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells
Bằng: Ana Jimenez-Pascual, et al.
Được phát hành: (2020-01-01)

Adamdec1, Ednrb and Ptgs1/Cox1, inflammation genes upregulated in the intestinal mucosa of obese rats, are downregulated by three probiotic strains
Bằng: Julio Plaza-Díaz, et al.
Được phát hành: (2017-05-01)

Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.
Bằng: Yamamoto, K, et al.
Được phát hành: (2014)

Disintegrins from Hematophagous Sources
Bằng: Ivo M. B. Francischetti, et al.
Được phát hành: (2012-04-01)

Snake Venom Disintegrins and Cell Migration
Bằng: Heloisa S. Selistre-de-Araujo, et al.
Được phát hành: (2010-10-01)

Proteolytic fragments of tenascin-C promote cartilage degradation
Bằng: Sofat, N, et al.
Được phát hành: (2010)

Trypanosoma cruzy proteolytic activities after immunoprecipitation with the monoclonal antibody H1A10
Bằng: Eloise Cedro Fernandes
Được phát hành: (2018-01-01)

Aggrecan breakdown in cartilage induced by proteolytic fragments of fibronectin: implications in osteoarthritis
Bằng: Nagase, H
Được phát hành: (2009)

The Role of Snake Venom Disintegrins in Angiogenesis
Bằng: Patricia Bianca Clissa, et al.
Được phát hành: (2024-03-01)

Recombinant and Chimeric Disintegrins in Preclinical Research
Bằng: Victor David, et al.
Được phát hành: (2018-08-01)

Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases
Bằng: D. Dreymueller, et al.
Được phát hành: (2017-01-01)

Voltage-Gated Calcium Channel alpha(2)delta Subunits in Lipid Rafts: The Importance of Proteolytic Cleavage Into alpha(2) and delta
Bằng: Kadurin, I, et al.
Được phát hành: (2012)

Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis
Bằng: Boeddha, NP, et al.
Được phát hành: (2021)

Proteolytic cleavage of antigen extends the durability of an anti-PCSK9 monoclonal antibody[S]
Bằng: Krista M. Schroeder, et al.
Được phát hành: (2015-11-01)

Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis
Bằng: Navin P. Boeddha, MD, PhD, et al.
Được phát hành: (2021-11-01)

Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B
Bằng: Yongfeng Fan, et al.
Được phát hành: (2015-08-01)

Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.
Bằng: Lauer-Fields, J, et al.
Được phát hành: (2008)

A Disintegrin and Metalloprotease 33 polymorphisms and lung function decline in the general population
Bằng: Cleo. C. van Diemen, et al.
Được phát hành: (2006-12-01)

Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity
Bằng: Gossens, K, et al.
Được phát hành: (2010)

Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity.
Bằng: Gossens, K, et al.
Được phát hành: (2010)

A DISINTEGRIN AND METALLOPROTEASE 17 IN THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMS
Bằng: Jiaxi Xu, et al.
Được phát hành: (2016-10-01)

A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions
Bằng: Nives Giebeler, et al.
Được phát hành: (2016-04-01)

ADAM-15 Disintegrin-Like Domain Structure and Function
Bằng: Dong Lu, et al.
Được phát hành: (2010-10-01)

A Disintegrin and Metalloproteinase—Control Elements in Infectious Diseases
Bằng: Ahmad Aljohmani, et al.
Được phát hành: (2020-12-01)

MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms
Bằng: Gifford, V, et al.
Được phát hành: (2019)

Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration
Bằng: Gregor Bieri, et al.
Được phát hành: (2018-12-01)

THE TYPE III 8-10 REPEATS OF FIBRONECTIN INDUCE AGGRECANASE ACTIVITY VIA ALPHA5BETA1 INTEGRIN AND THE TYPE III 13-14 REPEATS ACT VIA TLR 4 RECEPTORS
Bằng: Sofat, N, et al.
Được phát hành: (2009)

The type III 8-10 repeats of fibronectin induce aggrecanase activity via alpha(5)beta(1) integrin and type III 13-14 repeats act via TLR 4 receptors
Bằng: Sofat, N, et al.
Được phát hành: (2009)

Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.
Bằng: Kashiwagi, M, et al.
Được phát hành: (2004)

ADAM15 Disintegrin Is Associated with Aggressive Prostate and Breast Cancer Disease
Bằng: Rainer Kuefer, et al.
Được phát hành: (2006-04-01)

Snake venom disintegrins update: insights about new findings
Bằng: Gabriela de Oliveira Almeida, et al.
Được phát hành: (2023-09-01)

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
Bằng: Gendron, C, et al.
Được phát hành: (2007)

Monitoring metalloproteinase activity using synthetic fluorogenic substrates.
Bằng: Troeberg, L, et al.
Được phát hành: (2004)

Calcium pentosan polysulfate is a multi-functional aggrecanase inhibitor that enhances interaction with endogenous TIMP-3 in cartilage
Bằng: Troeberg, L, et al.
Được phát hành: (2009)

Proteases involved in cartilage matrix degradation in osteoarthritis.
Bằng: Troeberg, L, et al.
Được phát hành: (2012)

Measurement of matrix metalloproteinase activities in the medium of cultured synoviocytes using zymography.
Bằng: Troeberg, L, et al.
Được phát hành: (2003)

Zymography of metalloproteinases.
Bằng: Troeberg, L, et al.
Được phát hành: (2004)