Preconditioning of cardiosphere-derived cells With hypoxia or prolyl-4-hydroxylase inhibitors increases stemness and decreases reliance on oxidative metabolism

Cardiosphere-derived cells (CDCs), which can be isolated from heart explants, are a promising candidate cell source for infarcted myocardium regeneration. However, current protocols used to expand CDCs require at least 1 month in vitro to obtain sufficient cells for transplantation. We report that C...

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Bibliographic Details
Main Authors: Tan, S, Gomes, R, Yeoh, K, Perbellini, F, Malandraki-Miller, S, Ambrose, L, Heather, L, Faggian, G, Schofield, C, Davies, K, Clarke, K, Carr, C
Format: Journal article
Language:English
Published: Cognizant Communication Corporation 2015