Modulation of interleukin 1 beta gene expression using antisense phosphorothioate oligonucleotides.
The production of interleukin 1 beta (IL1 beta) in lipopolysaccharide (LPS) stimulated monocytes was inhibited by 98% using antisense phosphorothioate oligonucleotides complementary to the 5' untranslated and exon 6 regions of IL1 beta mRNA. A sense phosphorothioate oligonucleotide failed to in...
| Auteurs principaux: | , , |
|---|---|
| Format: | Journal article |
| Langue: | English |
| Publié: |
1990
|