An inhibitor of complement C5 provides structural insights into activation

The complement system is a crucial part of innate immune defenses against invading pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must therefore rely on inhibitors to counter complement activation. We have identified a class of inhibitors from tick saliva...

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Hlavní autoři: Reichhardt, M, Johnson, S, Tang, T, Morgan, T, Tebeka, N, Popitsch, N, Deme, J, Jore, M, Lea, S
Médium: Journal article
Jazyk:English
Vydáno: National Academy of Sciences 2019