The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.

The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain unidentified. We report that PGRN bound directly to tumor necrosis factor receptors (TNFRs) and disturbed the TNFα-TNFR interaction. PGRN-defici...

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Bibliographic Details
Main Authors: Tang, W, Lu, Y, Tian, Q, Zhang, Y, Guo, F, Liu, G, Syed, N, Lai, Y, Lin, E, Kong, L, Su, J, Yin, F, Ding, A, Zanin-Zhorov, A, Dustin, M, Tao, J, Craft, J, Yin, Z, Feng, J, Abramson, S, Yu, X, Liu, C
Format: Journal article
Language:English
Published: 2011

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