High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

BACKGROUND: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH, EC 1.1.1.141) is the key enzyme for the inactivation of prostaglandins, regulating processes such as inflammation or proliferation. The anabolic pathways of prostaglandins, especially with respect to regulation of the cyclooxygenase (COX)...

詳細記述

書誌詳細
主要な著者: Niesen, F, Schultz, L, Jadhav, A, Bhatia, C, Guo, K, Maloney, D, Pilka, E, Wang, M, Oppermann, U, Heightman, T, Simeonov, A
フォーマット: Journal article
言語:English
出版事項: Public Library of Science 2010