Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4

The antiviral activity of UV-4 was previously demonstrated against dengue virus serotype 2 (DENV2) in multiple mouse models. Herein, step-wise minimal effective dose and therapeutic window of efficacy studies of UV-4B (UV-4 hydrochloride salt) were conducted in an antibody-dependent enhancement (ADE...

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Những tác giả chính:	Warfield, KL, Plummer, EM, Sayce, AC, Alonzi, DS, Tang, W, Tyrrell, BE, Hill, ML, Caputo, AT, Killingbeck, SS, Beatty, PR, Harris, E, Iwaki, R, Kinami, K, Ide, D, Kiappes, JL, Kato, A, Buck, MD, King, K, Eddy, W, Khaliq, M, Sampath, A, Treston, AM, Dwek, RA, Enterlein, SG, Miller, JL, Zitzmann, N, Ramstedt, U, Shresta, S
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Elsevier 2016

Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4

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