Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.

The telomere repeat-binding factor 1 (TERF1, referred to hereafter as TRF1) is a component of mammalian telomeres whose role in telomere biology and disease has remained elusive. Here, we report on cells and mice conditionally deleted for TRF1. TRF1-deleted mouse embryonic fibroblasts (MEFs) show ra...

書誌詳細
主要な著者:	Martínez, P, Thanasoula, M, Muñoz, P, Liao, C, Tejera, A, McNees, C, Flores, J, Fernández-Capetillo, O, Tarsounas, M, Blasco, M
フォーマット:	Journal article
言語:	English
出版事項:	2009

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