Enantioselective total synthesis of (−)-Himalensine A via a palladium and 4-hydroxyproline co-catalyzed desymmetrization of vinyl-bromide-tethered cyclohexanones
Herein, we describe the convergent enantioselective total synthesis of himalensine A in 18 steps, enabled by a highly enantio- and diastereoselective construction of the morphan core via a palladium/hydroxy proline co-catalyzed desymmetrization of vinyl-bromide-tethered cyclohexanones. The reaction...
मुख्य लेखकों: | Kučera, R, Ellis, SR, Yamazaki, K, Hayward Cooke, J, Chekshin, N, Christensen, KE, Hamlin, TA, Dixon, DJ |
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स्वरूप: | Journal article |
भाषा: | English |
प्रकाशित: |
American Chemical Society
2023
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