Enantioselective total synthesis of (−)-Himalensine A via a palladium and 4-hydroxyproline co-catalyzed desymmetrization of vinyl-bromide-tethered cyclohexanones

Enantioselective total synthesis of (−)-Himalensine A via a palladium and 4-hydroxyproline co-catalyzed desymmetrization of vinyl-bromide-tethered cyclohexanones

Herein, we describe the convergent enantioselective total synthesis of himalensine A in 18 steps, enabled by a highly enantio- and diastereoselective construction of the morphan core via a palladium/hydroxy proline co-catalyzed desymmetrization of vinyl-bromide-tethered cyclohexanones. The reaction...

書目詳細資料
Main Authors:	Kučera, R, Ellis, SR, Yamazaki, K, Hayward Cooke, J, Chekshin, N, Christensen, KE, Hamlin, TA, Dixon, DJ
格式:	Journal article
語言:	English
出版:	American Chemical Society 2023

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