Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts.
OBJECTIVE: High levels of interleukin-6 (IL-6) have been found in the synovial fluid of patients with rheumatoid arthritis (RA). We undertook the present study to investigate the role of IL-6 in this disease. METHODS: We examined the effects of IL-6, in comparison with IL-1, on the biosynthesis of e...
| Główni autorzy: | , , , , |
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| Format: | Journal article |
| Język: | English |
| Wydane: |
1992
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| _version_ | 1826292471866327040 |
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| author | Ito, A Itoh, Y Sasaguri, Y Morimatsu, M Mori, Y |
| author_facet | Ito, A Itoh, Y Sasaguri, Y Morimatsu, M Mori, Y |
| author_sort | Ito, A |
| collection | OXFORD |
| description | OBJECTIVE: High levels of interleukin-6 (IL-6) have been found in the synovial fluid of patients with rheumatoid arthritis (RA). We undertook the present study to investigate the role of IL-6 in this disease. METHODS: We examined the effects of IL-6, in comparison with IL-1, on the biosynthesis of extracellular matrix macromolecules and of matrix-degrading proteinases in rheumatoid synovial fibroblasts. RESULTS: In rheumatoid synovial fibroblasts, IL-6 by itself enhanced the production of plasminogen activator, its inhibitor, and tissue inhibitor of metalloproteinases, whereas it did not modulate the biosynthesis of precursor of matrix metalloproteinase 1 (proMMP-1) (tissue collagenase), proMMP-3 (stromelysin), or connective tissue components. However, IL-1-induced production of proMMP-1 and proMMP-3 was preferentially augmented by IL-6. CONCLUSION: These results suggest that in RA, IL-6 may participate along with IL-1 in fine tuning of the catabolism of connective tissue components, by modulating the balance between connective tissue-degrading enzymes and their inhibitors. |
| first_indexed | 2024-03-07T03:15:13Z |
| format | Journal article |
| id | oxford-uuid:b58f5f9c-0242-4492-8579-56e965dd818b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:15:13Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:b58f5f9c-0242-4492-8579-56e965dd818b2022-03-27T04:34:19ZEffects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b58f5f9c-0242-4492-8579-56e965dd818bEnglishSymplectic Elements at Oxford1992Ito, AItoh, YSasaguri, YMorimatsu, MMori, YOBJECTIVE: High levels of interleukin-6 (IL-6) have been found in the synovial fluid of patients with rheumatoid arthritis (RA). We undertook the present study to investigate the role of IL-6 in this disease. METHODS: We examined the effects of IL-6, in comparison with IL-1, on the biosynthesis of extracellular matrix macromolecules and of matrix-degrading proteinases in rheumatoid synovial fibroblasts. RESULTS: In rheumatoid synovial fibroblasts, IL-6 by itself enhanced the production of plasminogen activator, its inhibitor, and tissue inhibitor of metalloproteinases, whereas it did not modulate the biosynthesis of precursor of matrix metalloproteinase 1 (proMMP-1) (tissue collagenase), proMMP-3 (stromelysin), or connective tissue components. However, IL-1-induced production of proMMP-1 and proMMP-3 was preferentially augmented by IL-6. CONCLUSION: These results suggest that in RA, IL-6 may participate along with IL-1 in fine tuning of the catabolism of connective tissue components, by modulating the balance between connective tissue-degrading enzymes and their inhibitors. |
| spellingShingle | Ito, A Itoh, Y Sasaguri, Y Morimatsu, M Mori, Y Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts. |
| title | Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts. |
| title_full | Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts. |
| title_fullStr | Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts. |
| title_full_unstemmed | Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts. |
| title_short | Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts. |
| title_sort | effects of interleukin 6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts |
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