Structural basis of positive modulation of type-A GABA receptors

Structural basis of positive modulation of type-A GABA receptors

<p>The GABA<sub>A</sub>Rs is the main inhibitory neurotransmitter receptor in the brain, and is primarily responsible for maintaining the excitatory-inhibitory balance in neurons on which normal function of the nervous system depends. This receptor is subject to modulation by sever...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Scott, SJ
Awduron Eraill:	Aricescu, AR
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2018
Pynciau:	Biology

Eitemau Tebyg

Structure-Dependent Activity of Natural GABA(A) Receptor Modulators
gan: Serhat Sezai Çiçek
Cyhoeddwyd: (2018-06-01)

Structural basis for distinctive receptor tropism of emerging paramyxoviruses
gan: Stelfox, A
Cyhoeddwyd: (2020)

The structural basis of immune receptor signalling
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Cyhoeddwyd: (2008)

From TgO/GABA-AT, GABA, and T-263 Mutant to Conception of Toxoplasma
gan: Joseph Lykins, et al.
Cyhoeddwyd: (2024-01-01)

Announcing the novel class of GABA–A receptor selective positive allosteric modulator antidepressants
gan: Olumuyiwa John Fasipe, et al.
Cyhoeddwyd: (2021-02-01)

Structural basis for ligand recognition and activation of the prostanoid receptors
gan: Xiu Li, et al.
Cyhoeddwyd: (2024-03-01)

Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication
gan: Jide Tian, et al.
Cyhoeddwyd: (2017-03-01)

Structural pharmacology of GABAА receptors
gan: Alexey V. Rossokhin, et al.
Cyhoeddwyd: (2021-12-01)

Structural basis of ligand recognition in 5-HT3 receptors
gan: Thompson, Andrew J., et al.
Cyhoeddwyd: (2013)

Decoding the structural basis of ligand recognition and biased signaling in the motilin receptor
gan: Chongzhao You, et al.
Cyhoeddwyd: (2025-03-01)

Structural basis of human Slo2.2 channel gating and modulation
gan: Jiangtao Zhang, et al.
Cyhoeddwyd: (2023-08-01)

Epipregnanolone as a Positive Modulator of GABA<sub>A</sub> Receptor in Rat Cerebellar and Hippocampus Neurons
gan: Julia Bukanova, et al.
Cyhoeddwyd: (2021-05-01)

Structural studies of human GABA-A receptors
gan: Masiulis, S
Cyhoeddwyd: (2017)

GABA(B) receptor modulation of feedforward inhibition through hippocampal neurogliaform cells.
gan: Price, C, et al.
Cyhoeddwyd: (2008)

Structural basis for pharmacological modulation of the TRPC6 channel
gan: Yonghong Bai, et al.
Cyhoeddwyd: (2020-03-01)

Structural basis for ligand recognition of the human hydroxycarboxylic acid receptor HCAR3
gan: Fang Ye, et al.
Cyhoeddwyd: (2024-11-01)

Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor
gan: Shiyi Shen, et al.
Cyhoeddwyd: (2024-07-01)

Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization
gan: Alexa Strauss, et al.
Cyhoeddwyd: (2024-08-01)

A Clinically Applicable Positive Allosteric Modulator of GABA Receptors Promotes Human β-Cell Replication and Survival as well as GABA’s Ability to Inhibit Inflammatory T Cells
gan: Jide Tian, et al.
Cyhoeddwyd: (2019-01-01)

Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity
gan: Silvia Panarello, et al.
Cyhoeddwyd: (2024-06-01)

Serotonin/GABA receptors modulate odor input to olfactory receptor neuron in locusts
gan: Mingyue Lv, et al.
Cyhoeddwyd: (2023-04-01)

Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABA<sub>A</sub> Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor
gan: Spencer R. Pierce, et al.
Cyhoeddwyd: (2023-04-01)

Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents
gan: Frank Mazza, et al.
Cyhoeddwyd: (2025-03-01)

Positive Allosteric Modulator of GABA Lowers BOLD Responses in the Cingulate Cortex.
gan: Susanna A Walter, et al.
Cyhoeddwyd: (2016-01-01)

Benzodiazepine Modulation of GABA<sub>A</sub> Receptors: A Mechanistic Perspective
gan: Marcel P. Goldschen-Ohm
Cyhoeddwyd: (2022-11-01)

The structural basis of RNA-catalyzed RNA polymerization
gan: Shechner, David M
Cyhoeddwyd: (2010)

Crystal structure of the GABA(A)-receptor-associated protein, GABARAP.
gan: Bavro, V, et al.
Cyhoeddwyd: (2002)

Brexanolone: an allosteric modulator of GABA-A receptors in the rapid treatment of postpartum depression
gan: Samet Kose, et al.
Cyhoeddwyd: (2017-10-01)

Experimental GABA A Receptor Agonists and Allosteric Modulators for the Treatment of Focal Epilepsy
gan: Janković SM, et al.
Cyhoeddwyd: (2021-03-01)

Reduction of false positives in structure-based virtual screening when receptor plasticity is considered
gan: Awuni, Yaw, et al.
Cyhoeddwyd: (2015)

Neurosteroid Modulation of Synaptic and Extrasynaptic GABA<sub>A</sub> Receptors of the Mouse Nucleus Accumbens
gan: Scott J. Mitchell, et al.
Cyhoeddwyd: (2024-04-01)

Neurobiology and Therapeutic Potential of α5-GABA Type A Receptors
gan: Tija C. Jacob
Cyhoeddwyd: (2019-07-01)

Neurosteroids and GABA-A receptor function
gan: Mingde eWang
Cyhoeddwyd: (2011-10-01)

Transgenic line for characterizing GABA-receptor expression to study the neural basis of olfaction in the yellow-fever mosquito
gan: Angela Rouyar, et al.
Cyhoeddwyd: (2024-03-01)

Neuronal Gamma-Aminobutyric Acid (GABA) Type A Receptors Undergo Cognate Ligand Chaperoning in the Endoplasmic Reticulum by Endogenous GABA
gan: Ping eWang, et al.
Cyhoeddwyd: (2015-05-01)

PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia
gan: Changyu Jiang, et al.
Cyhoeddwyd: (2020-10-01)

Structures of activin ligand traps using natural sets of type I and type II TGFβ receptors
gan: Erich J. Goebel, et al.
Cyhoeddwyd: (2022-01-01)

Positive selection within the Schizophrenia-associated GABA(A) receptor beta(2) gene.
gan: Wing-Sze Lo, et al.
Cyhoeddwyd: (2007-01-01)

GABA-A receptor modulating steroids in acute and chronic stress; relevance for cognition and dementia?
gan: S.K.S. Bengtsson, et al.
Cyhoeddwyd: (2020-05-01)

Structural basis of substrate binding specificity revealed by the crystal structures of polyamine receptors SpuD and SpuE from pseudomonas aeruginosa
gan: Wu, Donghui, et al.
Cyhoeddwyd: (2013)