A concise and efficient synthesis of (-)-allosamizoline.

A regio- and stereocontrolled total synthesis of (-)-allosamizoline is described. The key steps for this synthesis are ring-closing metathesis to form the cyclopentene core, halocyclization to afford the oxazoline ring, and finally stereoselective alkene radical addition followed by an alkene isomer...

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Auteurs principaux: Donohoe, T, Rosa, C
Format: Journal article
Langue:English
Publié: 2007