SYNTHESIS OF THE ALPHA-MANNOSIDASE INHIBITORS SWAINSONINE [(1S, 2R, 8R, 8AR)-1,2,8-TRIHYDROXYOCTAHYDROINDOLIZINE] AND 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL FROM MANNOSE
Benzyl 4-azido-4-deoxy-2,3-0-isopropylidene-α-D-mannopyranoside is a key intermediate in the syntheses of the α-mannosidase inhibitors, swainsonine [(1S, 2R, 8R, 8aR)-1, 2,8-trihydroxyoctahydroindolizine] and 1,4-dideoxy-1,4-imino-D-mannitol, and of the α-galactosidase inhibitor 1,4-dideoxy-1,4-imin...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1987
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