SYNTHESIS OF THE ALPHA-MANNOSIDASE INHIBITORS SWAINSONINE [(1S, 2R, 8R, 8AR)-1,2,8-TRIHYDROXYOCTAHYDROINDOLIZINE] AND 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL FROM MANNOSE
Benzyl 4-azido-4-deoxy-2,3-0-isopropylidene-α-D-mannopyranoside is a key intermediate in the syntheses of the α-mannosidase inhibitors, swainsonine [(1S, 2R, 8R, 8aR)-1, 2,8-trihydroxyoctahydroindolizine] and 1,4-dideoxy-1,4-imino-D-mannitol, and of the α-galactosidase inhibitor 1,4-dideoxy-1,4-imin...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1987
|
| _version_ | 1797090259407732736 |
|---|---|
| author | Bashyal, B Fleet, G Gough, M Smith, P |
| author_facet | Bashyal, B Fleet, G Gough, M Smith, P |
| author_sort | Bashyal, B |
| collection | OXFORD |
| description | Benzyl 4-azido-4-deoxy-2,3-0-isopropylidene-α-D-mannopyranoside is a key intermediate in the syntheses of the α-mannosidase inhibitors, swainsonine [(1S, 2R, 8R, 8aR)-1, 2,8-trihydroxyoctahydroindolizine] and 1,4-dideoxy-1,4-imino-D-mannitol, and of the α-galactosidase inhibitor 1,4-dideoxy-1,4-imino-D-lyxitol, from mannose. © 1987. |
| first_indexed | 2024-03-07T03:15:57Z |
| format | Journal article |
| id | oxford-uuid:b5c6808e-2fae-47f3-a122-9d47a1c70044 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:15:57Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:b5c6808e-2fae-47f3-a122-9d47a1c700442022-03-27T04:36:08ZSYNTHESIS OF THE ALPHA-MANNOSIDASE INHIBITORS SWAINSONINE [(1S, 2R, 8R, 8AR)-1,2,8-TRIHYDROXYOCTAHYDROINDOLIZINE] AND 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL FROM MANNOSEJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b5c6808e-2fae-47f3-a122-9d47a1c70044EnglishSymplectic Elements at Oxford1987Bashyal, BFleet, GGough, MSmith, PBenzyl 4-azido-4-deoxy-2,3-0-isopropylidene-α-D-mannopyranoside is a key intermediate in the syntheses of the α-mannosidase inhibitors, swainsonine [(1S, 2R, 8R, 8aR)-1, 2,8-trihydroxyoctahydroindolizine] and 1,4-dideoxy-1,4-imino-D-mannitol, and of the α-galactosidase inhibitor 1,4-dideoxy-1,4-imino-D-lyxitol, from mannose. © 1987. |
| spellingShingle | Bashyal, B Fleet, G Gough, M Smith, P SYNTHESIS OF THE ALPHA-MANNOSIDASE INHIBITORS SWAINSONINE [(1S, 2R, 8R, 8AR)-1,2,8-TRIHYDROXYOCTAHYDROINDOLIZINE] AND 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL FROM MANNOSE |
| title | SYNTHESIS OF THE ALPHA-MANNOSIDASE INHIBITORS SWAINSONINE [(1S, 2R, 8R, 8AR)-1,2,8-TRIHYDROXYOCTAHYDROINDOLIZINE] AND 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL FROM MANNOSE |
| title_full | SYNTHESIS OF THE ALPHA-MANNOSIDASE INHIBITORS SWAINSONINE [(1S, 2R, 8R, 8AR)-1,2,8-TRIHYDROXYOCTAHYDROINDOLIZINE] AND 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL FROM MANNOSE |
| title_fullStr | SYNTHESIS OF THE ALPHA-MANNOSIDASE INHIBITORS SWAINSONINE [(1S, 2R, 8R, 8AR)-1,2,8-TRIHYDROXYOCTAHYDROINDOLIZINE] AND 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL FROM MANNOSE |
| title_full_unstemmed | SYNTHESIS OF THE ALPHA-MANNOSIDASE INHIBITORS SWAINSONINE [(1S, 2R, 8R, 8AR)-1,2,8-TRIHYDROXYOCTAHYDROINDOLIZINE] AND 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL FROM MANNOSE |
| title_short | SYNTHESIS OF THE ALPHA-MANNOSIDASE INHIBITORS SWAINSONINE [(1S, 2R, 8R, 8AR)-1,2,8-TRIHYDROXYOCTAHYDROINDOLIZINE] AND 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL FROM MANNOSE |
| title_sort | synthesis of the alpha mannosidase inhibitors swainsonine 1s 2r 8r 8ar 1 2 8 trihydroxyoctahydroindolizine and 1 4 dideoxy 1 4 imino d mannitol from mannose |
| work_keys_str_mv | AT bashyalb synthesisofthealphamannosidaseinhibitorsswainsonine1s2r8r8ar128trihydroxyoctahydroindolizineand14dideoxy14iminodmannitolfrommannose AT fleetg synthesisofthealphamannosidaseinhibitorsswainsonine1s2r8r8ar128trihydroxyoctahydroindolizineand14dideoxy14iminodmannitolfrommannose AT goughm synthesisofthealphamannosidaseinhibitorsswainsonine1s2r8r8ar128trihydroxyoctahydroindolizineand14dideoxy14iminodmannitolfrommannose AT smithp synthesisofthealphamannosidaseinhibitorsswainsonine1s2r8r8ar128trihydroxyoctahydroindolizineand14dideoxy14iminodmannitolfrommannose |