Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.
Many individuals with multiple or large colorectal adenomas or early-onset colorectal cancer (CRC) have no detectable germline mutations in the known cancer predisposition genes. Using whole-genome sequencing, supplemented by linkage and association analysis, we identified specific heterozygous POLE...
主要な著者: | , , , , , , , , , , , , , , , , , , , , , , , , |
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フォーマット: | Journal article |
言語: | English |
出版事項: |
2013
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