Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds.

Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds.

The age of onset of Huntington's disease (HD) is inversely correlated with the CAG length in the HD gene. The CAG repeat length accounts for 70% of the variability in HD age of onset. However, 90% of individuals worldwide with expanded alleles possess between 40 and 50 CAG repeat lengths in the...

书目详细资料
Main Authors:	Gayán, J, Brocklebank, D, Andresen, J, Alkorta-Aranburu, G, Zameel Cader, M, Roberts, SA, Cherny, S, Wexler, N, Cardon, L, Housman, D
格式:	Journal article
语言:	English
出版:	2008

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