Mutational analysis of the PA and PB2 subunits of the influenza RNA polymerase complex leads to new insights into function

Míreanna comhchosúla

• A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs.
  de réir: Fodor, E, et al.
  Foilsithe / Cruthaithe: (2002)
• Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap binding.
  de réir: Fechter, P, et al.
  Foilsithe / Cruthaithe: (2003)
• A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase promotes the generation of defective interfering RNAs.
  de réir: Fodor, E, et al.
  Foilsithe / Cruthaithe: (2003)
• In vitro assembly of PB2 with a PB1-PA dimer supports a new model of assembly of influenza A virus polymerase subunits into a functional trimeric complex.
  de réir: Deng, T, et al.
  Foilsithe / Cruthaithe: (2005)
• The PA subunit is required for efficient nuclear accumulation of the PB1 subunit of the influenza A virus RNA polymerase complex.
  de réir: Fodor, E, et al.
  Foilsithe / Cruthaithe: (2004)