Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription

<p>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. It has a positive sense RNA genome that also serves as the mRNA for four non-structural proteins (nsPs) representing subunits of the viral replicase. Coupling of nsP and RNA synthesis complicates analysis of viral RNA replication. We...

Full description

Bibliographic Details
Main Authors: Utt, A, Rausalu, K, Jakobson, M, Männik, A, Alphey, L, Fragkoudis, R, Merits, A
Format: Journal article
Language:English
Published: American Society for Microbiology 2019