Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.

The dual specific kinase SAPK/ERK1 kinase (SEK1; mitogen-activated protein kinase kinase 4/Jun NH2 terminal kinase [ JNK] kinase) is a direct activator of stress-activated protein kinases ([SAPKs]/JNKs) in response to CD28 costimulation, CD40 signaling, or activation of the germinal center kinase. H...

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Bibliographic Details
Main Authors:	Nishina, H, Bachmann, M, Oliveira-dos-Santos, A, Kozieradzki, I, Fischer, K, Odermatt, B, Wakeham, A, Shahinian, A, Takimoto, H, Bernstein, A, Mak, T, Woodgett, JR, Ohashi, P, Penninger, J
Format:	Journal article
Language:	English
Published:	1997

Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.

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