Creatine kinase-deficient hearts exhibit increased susceptibility to ischemia-reperfusion injury and impaired calcium homeostasis.

Creatine kinase-deficient hearts exhibit increased susceptibility to ischemia-reperfusion injury and impaired calcium homeostasis.

The creatine kinase (CK) system is involved in the rapid transport of high-energy phosphates from the mitochondria to the sites of maximal energy requirements such as myofibrils and sarcolemmal ion pumps. Hearts of mice with a combined knockout of cytosolic M-CK and mitochondrial CK (M/Mito-CK(-/-))...

Podrobná bibliografie
Hlavní autoři:	Spindler, M, Meyer, K, Strömer, H, Leupold, A, Boehm, E, Wagner, H, Neubauer, S
Médium:	Journal article
Jazyk:	English
Vydáno:	2004

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