Charge engineering reveals the roles of ionizable side chains in electrospray ionization mass spectrometry

Charge engineering reveals the roles of ionizable side chains in electrospray ionization mass spectrometry

In solution, the charge of a protein is intricately linked to its stability, but electrospray ionization distorts this connection, potentially limiting the ability of native mass spectrometry to inform about protein structure and dynamics. How the behavior of intact proteins in the gas phase depends...

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Бібліографічні деталі
Автори: Abramsson, ML, Sahin, C, Hopper, JTS, Branca, RMM, Danielsson, J, Xu, M, Chandler, SA, Österlund, N, Ilag, LL, Leppert, A, Costeira-Paulo, J, Lang, L, Teilum, K, Laganowsky, A, Benesch, JLP, Oliveberg, M, Robinson, CV, Marklund, EG, Allison, TM, Winther, JR, Landreh, M
Формат: Journal article
Мова:English
Опубліковано: American Chemical Society 2021

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