Base excision repair targets for cancer therapy.

Base excision repair targets for cancer therapy.

Cellular DNA repair is a frontline system that is responsible for maintaining genome integrity and thus preventing premature aging and cancer by repairing DNA lesions and strand breaks caused by endogenous and exogenous mutagens. However, it is also the principal cellular system in cancer cells that...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолч:	Dianov, G
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2011

Ижил төстэй зүйлс

Targeting base excision repair to improve cancer therapies.
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Monitoring base excision repair by in vitro assays.
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Base excision repair fidelity in normal and cancer cells.
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Mammalian base excision repair: the forgotten archangel.
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Co-ordination of base excision repair and genome stability.
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DNA repair fidelity of base excision repair pathways in human cell extracts.
-н: Zhang, Q, зэрэг
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The emerging role of Mule and ARF in the regulation of base excision repair.
-н: Khoronenkova, S, зэрэг
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The emerging role of Mule and ARF in the regulation of base excision repair
-н: Khoronenkova, S, зэрэг
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In vitro base excision repair using mammalian cell extracts.
-н: Parsons, J, зэрэг
Хэвлэсэн: (2012)

Orchestration of base excision repair by controlling the rates of enzymatic activities.
-н: Allinson, S, зэрэг
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DNA base excision repair: the Achilles' heel of tumour cells and their microenvironment?
-н: Poletto, M, зэрэг
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Exchangeability of mammalian DNA ligases between base excision repair pathways.
-н: Sleeth, K, зэрэг
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Monitoring base excision repair proteins on damaged DNA using human cell extracts.
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p53 coordinates base excision repair to prevent genomic instability
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Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy
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Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability
-н: Markkanen, E, зэрэг
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XRCC1-DNA polymerase beta interaction is required for efficient base excision repair.
-н: Dianova, I, зэрэг
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CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.
-н: Parsons, J, зэрэг
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DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.
-н: Parsons, J, зэрэг
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Isolation of a small molecule inhibitor of DNA base excision repair.
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Overexpression of DNA polymerase beta results in an increased rate of frameshift mutations during base excision repair.
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Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.
-н: Parsons, J, зэрэг
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Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy
-н: Shengyuan Zhao, зэрэг
Хэвлэсэн: (2022-02-01)

Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells
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Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients
-н: Chen, X, зэрэг
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USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.
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Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy.
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Regulation of the base excision repair pathway
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Base excision repair and the role of <it>MUTYH</it>
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Exploiting Base Excision Repair to Improve Therapeutic Approaches for Pancreatic Cancer
-н: George eSharbeen, зэрэг
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CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair.
-н: Ström, C, зэрэг
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Bacillus Calmette-Guerin Increases Base Excision Repair in Bladder Cancer Cells
-н: Selçuk Keskin, зэрэг
Хэвлэсэн: (2021-03-01)

Base Sequence Context Effects on Nucleotide Excision Repair
-н: Yuqin Cai, зэрэг
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The Base Excision Repair Pathway in the Nematode Caenorhabditis elegans
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Haglund Excision and Suture Bridge Repair
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Functional DNA repair capacity assays : a focus on base excision repair
-н: Chaim, Isaac Alexander
Хэвлэсэн: (2016)

Lycopene Protects against Smoking-Induced Lung Cancer by Inducing Base Excision Repair
-н: Junrui Cheng, зэрэг
Хэвлэсэн: (2020-07-01)

Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer.
-н: Kevin J Lee, зэрэг
Хэвлэсэн: (2019-01-01)

DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging
-н: Ricardo Gredilla
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OGG1 in Lung—More than Base Excision Repair
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