Micro-SPECT/CT with 111In-DTPA-pertuzumab sensitively detects trastuzumab-mediated HER2 downregulation and tumor response in athymic mice bearing MDA-MB-361 human breast cancer xenografts.

UNLABELLED: Pertuzumab is a HER2 dimerization inhibitor that binds to an epitope unique from that of trastuzumab. Our objective was to determine whether SPECT with (111)In-diethylenetriaminepentaacetic acid-pertuzumab ((111)In-DTPA-pertuzumab) could sensitively detect an early molecular response to...

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Détails bibliographiques
Auteurs principaux: McLarty, K, Cornelissen, B, Cai, Z, Scollard, D, Costantini, D, Done, S, Reilly, R
Format: Journal article
Langue:English
Publié: 2009