Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid–base transporters and auto-regulate cardiomyocyte pH

Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid–base transporters and auto-regulate cardiomyocyte pH

<p><strong>Aims</strong></p> In cardiomyocytes, acute disturbances to intracellular pH (pHi) are promptly corrected by a system of finely tuned sarcolemmal acid–base transporters. However, these fluxes become thermodynamically re-balanced in acidic environments, which inadver...

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Hlavní autoři: Wilson, AD, Richards, MA, Curtis, MK, Gunadasa-Rohling, M, Monterisi, S, Loonat, AA, Miller, JJ, Ball, V, Lewis, A, Tyler, DJ, Moshnikova, A, Andreev, OA, Reshetnyak, YK, Carr, C, Swietach, P
Médium: Journal article
Jazyk:English
Vydáno: Oxford University Press 2021

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