RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates

Increasing Neisseria gonorrhoeae resistance to ceftriaxone, the last antibiotic recommended for empiric gonorrhea treatment, poses an urgent public health threat. However, the genetic basis of reduced susceptibility to ceftriaxone is not completely understood: while most ceftriaxone resistance in cl...

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Bibliographic Details
Main Authors: Palace, SG, Wang, Y, Rubin, DH, Welsh, MA, Mortimer, TD, Cole, K, Eyre, DW, Walker, S, Grad, YH
Format: Journal article
Language:English
Published: eLife Sciences Publications 2020