Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.

Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.

Normal human erythroid cell maturation requests the transcription factor GATA-1 and a transient activation of caspase-3, with GATA-1 being protected from caspase-3-mediated cleavage by interaction with the chaperone heat shock protein 70 (Hsp70) in the nucleus. Erythroid cell dysplasia observed in e...

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Prif Awduron: Frisan, E, Vandekerckhove, J, de Thonel, A, Pierre-Eugène, C, Sternberg, A, Arlet, J, Floquet, C, Gyan, E, Kosmider, O, Dreyfus, F, Gabet, A, Courtois, G, Vyas, P, Ribeil, J, Zermati, Y, Lacombe, C, Mayeux, P, Solary, E, Garrido, C, Hermine, O, Fontenay, M
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2012

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