Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis.

Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis.

CONTEXT: Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome that precipitated early stopping. OBJECTIVE: To compare the treatment effect from truncated RCTs with that from met...

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Bibliographic Details
Main Authors: Bassler, D, Briel, M, Montori, V, Lane, M, Glasziou, P, Zhou, Q, Heels-Ansdell, D, Walter, S, Guyatt, G, Flynn, D, Elamin, M, Murad, M, Abu Elnour, N, Lampropulos, J, Sood, A, Mullan, R, Erwin, P, Bankhead, C, Perera, R, Ruiz Culebro, C, You, J, Mulla, S, Kaur, J, Nerenberg, K, Schünemann, H
Format: Journal article
Language:English
Published: 2010

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