High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people.

High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people.

The insulin-degrading enzyme is responsible for the intracellular proteolysis of insulin. Its gene IDE is located on chromosome 10, in an area with suggestive linkage to type 2 diabetes and related phenotypes. Due to the impact of genetic variants of this gene in rodents and the function of its prot...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Florez, J, Wiltshire, S, Agapakis, C, Burtt, N, de Bakker, P, Almgren, P, Bengtsson Boström, K, Tuomi, T, Gaudet, D, Daly, M, Hirschhorn, J, McCarthy, M, Altshuler, D, Groop, L
Format: Journal article
Sprache:English
Veröffentlicht: 2006

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