High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people.
The insulin-degrading enzyme is responsible for the intracellular proteolysis of insulin. Its gene IDE is located on chromosome 10, in an area with suggestive linkage to type 2 diabetes and related phenotypes. Due to the impact of genetic variants of this gene in rodents and the function of its prot...
Κύριοι συγγραφείς: | Florez, J, Wiltshire, S, Agapakis, C, Burtt, N, de Bakker, P, Almgren, P, Bengtsson Boström, K, Tuomi, T, Gaudet, D, Daly, M, Hirschhorn, J, McCarthy, M, Altshuler, D, Groop, L |
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Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
2006
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