Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infection.

HIV-1 often evades cytotoxic T cell (CTL) responses by generating variants that are not recognized by CTLs. We used single-genome amplification and sequencing of complete HIV genomes to identify longitudinal changes in the transmitted/founder virus from the establishment of infection to the viral se...

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Príomhchruthaitheoirí: Ganusov, V, Goonetilleke, N, Liu, M, Ferrari, G, Shaw, G, Mcmichael, A, Borrow, P, Korber, B, Perelson, A
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2011