Intramolecular general acid catalysis in the binding reactions of alpha 2-macroglobulin and complement components C3 and C4.
The complement system proteins C3 and C4 and the plasma protease inhibitor alpha 2-macroglobulin, when activated by limited proteolysis, can bind covalently to other macromolecules. The three proteins also exhibit an unusual internal peptide-bond cleavage reaction when denatured. The covalent bindin...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Kluwer Academic Publishers
1981
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