Swelling of the intervertebral disc in vitro.
Slices of the intervertebral disc swell rapidly in aqueous solutions. Following swelling, a large proportion of the proteoglycans leach out. These changes can introduce artifacts into in vitro experimental work. Swelling results from the large Gibbs-Donnan osmotic pressure of the proteoglycans which...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Informa Healthcare
1981
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| _version_ | 1797090750498865152 |
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| author | Urban, J Maroudas, A |
| author_facet | Urban, J Maroudas, A |
| author_sort | Urban, J |
| collection | OXFORD |
| description | Slices of the intervertebral disc swell rapidly in aqueous solutions. Following swelling, a large proportion of the proteoglycans leach out. These changes can introduce artifacts into in vitro experimental work. Swelling results from the large Gibbs-Donnan osmotic pressure of the proteoglycans which the collagen network of the disc is unable to oppose alone. Swelling can be prevented by applying pressure to disc slices either mechanically or with iso-osmotic solutions. |
| first_indexed | 2024-03-07T03:23:11Z |
| format | Journal article |
| id | oxford-uuid:b8244229-7302-4bfa-9577-615eb1ad3501 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:23:11Z |
| publishDate | 1981 |
| publisher | Informa Healthcare |
| record_format | dspace |
| spelling | oxford-uuid:b8244229-7302-4bfa-9577-615eb1ad35012022-03-27T04:53:47ZSwelling of the intervertebral disc in vitro.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b8244229-7302-4bfa-9577-615eb1ad3501EnglishSymplectic Elements at OxfordInforma Healthcare1981Urban, JMaroudas, ASlices of the intervertebral disc swell rapidly in aqueous solutions. Following swelling, a large proportion of the proteoglycans leach out. These changes can introduce artifacts into in vitro experimental work. Swelling results from the large Gibbs-Donnan osmotic pressure of the proteoglycans which the collagen network of the disc is unable to oppose alone. Swelling can be prevented by applying pressure to disc slices either mechanically or with iso-osmotic solutions. |
| spellingShingle | Urban, J Maroudas, A Swelling of the intervertebral disc in vitro. |
| title | Swelling of the intervertebral disc in vitro. |
| title_full | Swelling of the intervertebral disc in vitro. |
| title_fullStr | Swelling of the intervertebral disc in vitro. |
| title_full_unstemmed | Swelling of the intervertebral disc in vitro. |
| title_short | Swelling of the intervertebral disc in vitro. |
| title_sort | swelling of the intervertebral disc in vitro |
| work_keys_str_mv | AT urbanj swellingoftheintervertebraldiscinvitro AT maroudasa swellingoftheintervertebraldiscinvitro |