Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil.

Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil.

Although the intratumoral expression levels of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are known to affect the antitumor activity of 5-fluorouracil (5-FU), the importance of orotate phosphoribosyltransferase (OPRT) has remained unclear. This study investigated the relatio...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Sakamoto, E, Nagase, H, Kobunai, T, Oie, S, Oka, T, Fukushima, M
Format: Journal article
Sprache:English
Veröffentlicht: 2007

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