POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer

POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer

<strong>Purpose:</strong> Recent studies have shown that 7-12% of endometrial cancers (ECs) are ultramutated due to mutation in the proofreading exonuclease domain of the DNA replicase POLE. Interestingly, these tumors have an excellent prognosis. In view of the emerging data linking mut...

Cijeli opis

Bibliografski detalji
Glavni autori: Klenerman, P, Church, D, Tomlinson, I, van Gool, I, Eggink, F, Freeman-Mills, L, Stelloo, E, Marchi, E, de Bruyn, M, Palles, C, Nout, R, de Kroon, C, Osse, E, Creutzberg, C, Smit, V, Nijman, H, Bosse, T
Format: Journal article
Jezik:English
Izdano: American Association for Cancer Research 2015

Slični predmeti