Tumor-associated changes in intestinal epithelial cells cause local accumulation of KLRG1(+) GATA3(+) regulatory T cells in mice

Tumor-associated changes in intestinal epithelial cells cause local accumulation of KLRG1(+) GATA3(+) regulatory T cells in mice

CD4(+) Foxp3(+) regulatory T cells (Treg) include differentiated populations of effector Treg characterized by the expression of specific transcription factors. Tumors, including intestinal malignancies, often present with local accumulation of Treg that can prevent tumor clearance, but how tumor pr...

Descripció completa

Dades bibliogràfiques
Autors principals:	Meinicke, H, Bremser, A, Brack, M, Akeus, P, Pearson, C, Bullers, S, Hoffmeyer, K, Stemmler, M, Quiding-Järbrink, M, Izcue, A
Format:	Journal article
Idioma:	English
Publicat:	John Wiley & Sons Ltd 2017

Ítems similars

Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction.
per: Anna Bremser, et al.
Publicat: (2015-01-01)

β7 integrins contribute to intestinal tumor growth in mice.
per: Srustidhar Das, et al.
Publicat: (2018-01-01)

The Yin and Yang of Targeting KLRG1+ Tregs and Effector Cells
per: Samantha M. Borys, et al.
Publicat: (2022-04-01)

Accumulation of CCR4⁺CTLA-4 FOXP3⁺CD25(hi) regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells.
per: Helena Svensson, et al.
Publicat: (2012-01-01)

Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier.
per: Izcue, A, et al.
Publicat: (2008)

CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria.
per: Barnes, M, et al.
Publicat: (2013)

Early primed KLRG1- CMV-specific T cells determine the size of the inflationary T cell pool.
per: Nicolas S Baumann, et al.
Publicat: (2019-05-01)

Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori infection and gastric adenocarcinoma.
per: Enarsson, K, et al.
Publicat: (2006)

Prenatal tolerance--a role for regulatory T cells?
per: Izcue, A, et al.
Publicat: (2005)

572 PYX-102, an anti-KLRG1 antibody, enhances cytotoxic activity of CD8-T-cells from PBMC and human tumor samples by blocking the interaction between KLRG1 and cadherins
per: Ronald Herbst, et al.
Publicat: (2023-11-01)

Intratumoral regulatory T cells from colon cancer patients comprise several activated effector populations
per: Louis Szeponik, et al.
Publicat: (2021-08-01)

KLRG1-expressing CD8+ T cells are exhausted and polyfunctional in patients with chronic hepatitis B.
per: Li Wang, et al.
Publicat: (2024-01-01)

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation.
per: Izcue, A, et al.
Publicat: (2006)

GATA4 Regulates Epithelial Cell Proliferation to Control Intestinal Growth and Development in MiceSummary
per: Bridget M. Kohlnhofer, et al.
Publicat: (2016-03-01)

Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation.
per: Thimme, R, et al.
Publicat: (2005)

Expansion of CD57+KLRG1+ T cells is associated with reduced vaccine responses in CMV+ young adults
per: Bowyer, G, et al.
Publicat: (2020)

The role of KLRG1: a novel biomarker and new therapeutic target
per: Yakun Zhang, et al.
Publicat: (2024-06-01)

Functions and clinical significance of KLRG1 in the development of lung adenocarcinoma and immunotherapy
per: Xiaodong Yang, et al.
Publicat: (2021-06-01)

KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response
per: Charles G Drake, et al.
Publicat: (2023-09-01)

In Vivo Zymosan Treatment Induces IL15-Secreting Macrophages and KLRG1-Expressing NK Cells in Mice
per: Hyun Jung Park, et al.
Publicat: (2023-07-01)

Regulatory lymphocytes and intestinal inflammation.
per: Izcue, A, et al.
Publicat: (2009)

Enhanced M1 macrophage polarization in human helicobacter pylori-associated atrophic gastritis and in vaccinated mice.
per: Marianne Quiding-Järbrink, et al.
Publicat: (2010-01-01)

Immune checkpoint blockade improves the activation and function of circulating mucosal-associated invariant T (MAIT) cells in patients with non-small cell lung cancer
per: Patrik Sundström, et al.
Publicat: (2024-12-01)

Immune cell infiltrates in peritoneal metastases from colorectal cancer
per: Patrik Sundström, et al.
Publicat: (2024-02-01)

Dysregulation of peripheral and intratumoral KLRG1+ CD8+ T cells is associated with immune evasion in patients with non-small-cell lung cancer
per: Juan Zeng, et al.
Publicat: (2024-07-01)

Cover 1 - GATA4 Controls Gastric Columnar Epithelial Cell Development
Publicat: (2021-01-01)

KLRG1 and CD103 Expressions Define Distinct Intestinal Tissue-Resident Memory CD8 T Cell Subsets Modulated in Crohn's Disease
per: Hugo Bottois, et al.
Publicat: (2020-05-01)

GATA4 blocks squamous epithelial cell gene expression in human esophageal squamous cells
per: Roman Stavniichuk, et al.
Publicat: (2021-02-01)

Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation
per: Yumeng Sun, et al.
Publicat: (2025-02-01)

Reciprocal Interactions Between Regulatory T Cells and Intestinal Epithelial Cells
per: Zhiqiang Jiang, et al.
Publicat: (2022-07-01)

Increased KLRG1 and PD-1 expression on CD8 T lymphocytes in TB-IRIS.
per: Odin Goovaerts, et al.
Publicat: (2019-01-01)

PD-1 blockade potentiates neoadjuvant chemotherapy in NSCLC via increasing CD127+ and KLRG1+ CD8 T cells
per: Zhenzhen Hui, et al.
Publicat: (2023-05-01)

KLRG1 expression identifies short-lived Foxp3+ Treg effector cells with functional plasticity in islets of NOD mice
per: Mara Kornete, et al.
Publicat: (2017-08-01)

N-cadherin protects oral cancer cells from NK cell killing in the circulation by inducing NK cell functional exhaustion via the KLRG1 receptor
per: Qin Xu, et al.
Publicat: (2022-09-01)

CD154 blockade alters innate immune cell recruitment and programs alloreactive CD8+ T cells into KLRG-1(high) short-lived effector T cells.
per: Ivana R Ferrer, et al.
Publicat: (2012-01-01)

The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients
per: Tiantian Chen, et al.
Publicat: (2018-01-01)

Polyfunctional KLRG-1+CD57+ Senescent CD4+ T Cells Infiltrate Tumors and Are Expanded in Peripheral Blood From Breast Cancer Patients
per: Maria C. Ramello, et al.
Publicat: (2021-07-01)

Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis.
per: Izcue, A, et al.
Publicat: (2008)

Enhanced protection conferred by mucosal BCG vaccination associates with presence of antigen-specific lung tissue-resident PD-1+ KLRG1− CD4+ T cells
per: Bull, N, et al.
Publicat: (2018)

The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer
per: Leila Hosseinzadeh, et al.
Publicat: (2024-02-01)