Tumor-associated changes in intestinal epithelial cells cause local accumulation of KLRG1(+) GATA3(+) regulatory T cells in mice

Tumor-associated changes in intestinal epithelial cells cause local accumulation of KLRG1(+) GATA3(+) regulatory T cells in mice

CD4(+) Foxp3(+) regulatory T cells (Treg) include differentiated populations of effector Treg characterized by the expression of specific transcription factors. Tumors, including intestinal malignancies, often present with local accumulation of Treg that can prevent tumor clearance, but how tumor pr...

Podrobná bibliografie
Hlavní autoři:	Meinicke, H, Bremser, A, Brack, M, Akeus, P, Pearson, C, Bullers, S, Hoffmeyer, K, Stemmler, M, Quiding-Järbrink, M, Izcue, A
Médium:	Journal article
Jazyk:	English
Vydáno:	John Wiley & Sons Ltd 2017

Podobné jednotky

Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction.
Autor: Anna Bremser, a další
Vydáno: (2015-01-01)

β7 integrins contribute to intestinal tumor growth in mice.
Autor: Srustidhar Das, a další
Vydáno: (2018-01-01)

The Yin and Yang of Targeting KLRG1+ Tregs and Effector Cells
Autor: Samantha M. Borys, a další
Vydáno: (2022-04-01)

Accumulation of CCR4⁺CTLA-4 FOXP3⁺CD25(hi) regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells.
Autor: Helena Svensson, a další
Vydáno: (2012-01-01)

Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier.
Autor: Izcue, A, a další
Vydáno: (2008)

CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria.
Autor: Barnes, M, a další
Vydáno: (2013)

Early primed KLRG1- CMV-specific T cells determine the size of the inflationary T cell pool.
Autor: Nicolas S Baumann, a další
Vydáno: (2019-05-01)

Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori infection and gastric adenocarcinoma.
Autor: Enarsson, K, a další
Vydáno: (2006)

Prenatal tolerance--a role for regulatory T cells?
Autor: Izcue, A, a další
Vydáno: (2005)

572 PYX-102, an anti-KLRG1 antibody, enhances cytotoxic activity of CD8-T-cells from PBMC and human tumor samples by blocking the interaction between KLRG1 and cadherins
Autor: Ronald Herbst, a další
Vydáno: (2023-11-01)

Intratumoral regulatory T cells from colon cancer patients comprise several activated effector populations
Autor: Louis Szeponik, a další
Vydáno: (2021-08-01)

KLRG1-expressing CD8+ T cells are exhausted and polyfunctional in patients with chronic hepatitis B.
Autor: Li Wang, a další
Vydáno: (2024-01-01)

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation.
Autor: Izcue, A, a další
Vydáno: (2006)

GATA4 Regulates Epithelial Cell Proliferation to Control Intestinal Growth and Development in MiceSummary
Autor: Bridget M. Kohlnhofer, a další
Vydáno: (2016-03-01)

Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation.
Autor: Thimme, R, a další
Vydáno: (2005)

Expansion of CD57+KLRG1+ T cells is associated with reduced vaccine responses in CMV+ young adults
Autor: Bowyer, G, a další
Vydáno: (2020)

The role of KLRG1: a novel biomarker and new therapeutic target
Autor: Yakun Zhang, a další
Vydáno: (2024-06-01)

Functions and clinical significance of KLRG1 in the development of lung adenocarcinoma and immunotherapy
Autor: Xiaodong Yang, a další
Vydáno: (2021-06-01)

KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response
Autor: Charles G Drake, a další
Vydáno: (2023-09-01)

In Vivo Zymosan Treatment Induces IL15-Secreting Macrophages and KLRG1-Expressing NK Cells in Mice
Autor: Hyun Jung Park, a další
Vydáno: (2023-07-01)

Regulatory lymphocytes and intestinal inflammation.
Autor: Izcue, A, a další
Vydáno: (2009)

Enhanced M1 macrophage polarization in human helicobacter pylori-associated atrophic gastritis and in vaccinated mice.
Autor: Marianne Quiding-Järbrink, a další
Vydáno: (2010-01-01)

Immune checkpoint blockade improves the activation and function of circulating mucosal-associated invariant T (MAIT) cells in patients with non-small cell lung cancer
Autor: Patrik Sundström, a další
Vydáno: (2024-12-01)

Immune cell infiltrates in peritoneal metastases from colorectal cancer
Autor: Patrik Sundström, a další
Vydáno: (2024-02-01)

Dysregulation of peripheral and intratumoral KLRG1+ CD8+ T cells is associated with immune evasion in patients with non-small-cell lung cancer
Autor: Juan Zeng, a další
Vydáno: (2024-07-01)

Cover 1 - GATA4 Controls Gastric Columnar Epithelial Cell Development
Vydáno: (2021-01-01)

KLRG1 and CD103 Expressions Define Distinct Intestinal Tissue-Resident Memory CD8 T Cell Subsets Modulated in Crohn's Disease
Autor: Hugo Bottois, a další
Vydáno: (2020-05-01)

GATA4 blocks squamous epithelial cell gene expression in human esophageal squamous cells
Autor: Roman Stavniichuk, a další
Vydáno: (2021-02-01)

Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation
Autor: Yumeng Sun, a další
Vydáno: (2025-02-01)

Reciprocal Interactions Between Regulatory T Cells and Intestinal Epithelial Cells
Autor: Zhiqiang Jiang, a další
Vydáno: (2022-07-01)

Increased KLRG1 and PD-1 expression on CD8 T lymphocytes in TB-IRIS.
Autor: Odin Goovaerts, a další
Vydáno: (2019-01-01)

PD-1 blockade potentiates neoadjuvant chemotherapy in NSCLC via increasing CD127+ and KLRG1+ CD8 T cells
Autor: Zhenzhen Hui, a další
Vydáno: (2023-05-01)

KLRG1 expression identifies short-lived Foxp3+ Treg effector cells with functional plasticity in islets of NOD mice
Autor: Mara Kornete, a další
Vydáno: (2017-08-01)

N-cadherin protects oral cancer cells from NK cell killing in the circulation by inducing NK cell functional exhaustion via the KLRG1 receptor
Autor: Qin Xu, a další
Vydáno: (2022-09-01)

CD154 blockade alters innate immune cell recruitment and programs alloreactive CD8+ T cells into KLRG-1(high) short-lived effector T cells.
Autor: Ivana R Ferrer, a další
Vydáno: (2012-01-01)

The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients
Autor: Tiantian Chen, a další
Vydáno: (2018-01-01)

Polyfunctional KLRG-1+CD57+ Senescent CD4+ T Cells Infiltrate Tumors and Are Expanded in Peripheral Blood From Breast Cancer Patients
Autor: Maria C. Ramello, a další
Vydáno: (2021-07-01)

Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis.
Autor: Izcue, A, a další
Vydáno: (2008)

Enhanced protection conferred by mucosal BCG vaccination associates with presence of antigen-specific lung tissue-resident PD-1+ KLRG1− CD4+ T cells
Autor: Bull, N, a další
Vydáno: (2018)

The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer
Autor: Leila Hosseinzadeh, a další
Vydáno: (2024-02-01)