Transcriptome and genome evolution during HER2-amplified breast neoplasia

Background The acquisition of oncogenic drivers is a critical feature of cancer progression. For some carcinomas, it is clear that certain genetic drivers occur early in neoplasia and others late. Why these drivers are selected and how these changes alter the neoplasia’s fitness is less understood....

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Bibliographic Details
Main Authors: Lu, P, Foley, J, Zhu, C, McNamara, K, Sirinukunwattana, K, Vennam, S, Varma, S, Fehri, H, Srivastava, A, Zhu, S, Rittscher, J, Mallick, P, Curtis, C, West, R
Format: Journal article
Language:English
Published: BioMed Central 2021