Role of the Nav1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain.

OBJECTIVE: To assess the genetic association of pain in patients with knee osteoarthritis (OA) and those with multiple regional pain with the R1150W variant in the α-subunit of the voltage-gated sodium channel Na(V)1.7. METHODS: Knee OA patients from 2 UK cohorts (1,411 from the Genetics of Osteoart...

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Bibliographic Details
Main Authors: Valdes, A, Arden, N, Vaughn, F, Doherty, SA, Leaverton, P, Zhang, W, Muir, K, Rampersaud, E, Dennison, E, Edwards, M, Jameson, K, Javaid, M, Spector, T, Cooper, C, Maciewicz, R, Doherty, M
Format: Journal article
Language:English
Published: 2011