Structural and biochemical characterisation of human integral membrane proteins regarded as potential therapeutic targets

Structural and biochemical characterisation of human integral membrane proteins regarded as potential therapeutic targets

<p>Integral membrane proteins are responsible for a wide range of cellular functions and are important targets for the development of novel therapeutics. Therefore, obtaining structural and mechanistic insights into their function is of central importance for rational drug design. In this thes...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолч:	da Costa Cabral Gomes Páscoa, T
Бусад зохиолчид:	Carpenter, E
Формат:	Дипломын ажил
Хэл сонгох:	English
Хэвлэсэн:	2022
Нөхцлүүд:	Biochemistry Structural Biology

Ижил төстэй зүйлс

Biochemical characterisation of KDM2A
-н: Zhou, JC
Хэвлэсэн: (2012)

Characterisation of 2-oxoglutarate- and fe(II)-dependent oxygenases targeting the protein synthesis apparatus
-н: Feng, T
Хэвлэсэн: (2014)

Structural characterisation of calnexin cycle components and assessment as antiviral targets
-н: Hill, J
Хэвлэсэн: (2018)

Identification and characterisation of alternative forms of SETD2/HYPB (SET domain-containing protein 2 / Huntingtin yeast partner B)
-н: Lee, BM
Хэвлэсэн: (2011)

Biochemical studies of the cohesin complex
-н: Upcher, WR
Хэвлэсэн: (2012)

Biochemical and functional characterization of the RNA binding protein SAF-A/hnRNP U and investigation of its potential role in mammalian X chromosome inactivation
-н: Tattermusch, A
Хэвлэсэн: (2015)

Cryo-EM grid optimization for membrane proteins
-н: Domen Kampjut, зэрэг
Хэвлэсэн: (2021-03-01)

Structual and biochemical characterisation of the endoplasmic reticulum alpha-glucosidases
-н: Caputo, A
Хэвлэсэн: (2015)

Mass Photometry of Membrane Proteins
-н: Olerinyova, A, зэрэг
Хэвлэсэн: (2020)

Structural & biophysical characterisation of M. tuberculosis MmpL3
-н: Adams, O
Хэвлэсэн: (2021)

Structural and biophysical characterisation of marine viruses and amino acid transporters
-н: Gillum, A
Хэвлэсэн: (2018)

Therapeutic potential of promiscuous targets in Mycobacterium tuberculosis
-н: Lee, Bei Shi, зэрэг
Хэвлэсэн: (2020)

Role of mutual information for predicting contact residues in proteins
-н: Gomes, M
Хэвлэсэн: (2012)

Biochemical, structural and functional analysis of an engineered DNA architectural protein
-н: Bao, Qiuye
Хэвлэсэн: (2008)

Ancestral lysosomal enzymes with increased activity harbor therapeutic potential for treatment of Hunter syndrome
-н: Natalie M. Hendrikse, зэрэг
Хэвлэсэн: (2021-03-01)

Aging and cancer hallmarks as therapeutic targets
-н: Jingchao Wang, зэрэг
Хэвлэсэн: (2023-07-01)

Biochemical study of the interactions between cohesin and DNA
-н: Collier, JE
Хэвлэсэн: (2020)

Structural and biochemical study of Candida albicans polarisomal proteins
-н: Loh, Zhi Yang
Хэвлэсэн: (2021)

Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease
-н: Nanaka Kaneshiro, зэрэг
Хэвлэсэн: (2022-03-01)

Structural studies of integral membrane GPCR accessory proteins
-н: Sladek, B
Хэвлэсэн: (2013)

Molecular modeling and simulation for proteins and polymer membranes
-н: Christian, Bope Domilongo
Хэвлэсэн: (2017)

Fluorescence spectroscopy in biology : advanced methods and their applications to membranes, proteins, DNA, and cells /
-н: Fidler, V., зэрэг
Хэвлэсэн: (2005)

Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma
-н: Chuanxu Liu, зэрэг
Хэвлэсэн: (2023-08-01)

Expression of an inverted repeat of a target gene leads to specific disappearance of the corresponding mRNA and encoded protein.
-н: Bastin, P, зэрэг
Хэвлэсэн: (1999)

Characterisation of ant-1 as an inhibitor of myostatin activity.
-н: Irfana Begum Ikbal.
Хэвлэсэн: (2011)

Progressive structuring of a branched antimicrobial peptide on the path to the inner membrane target
-н: Beuerman, Roger W., зэрэг
Хэвлэсэн: (2013)

Investigating the non-protein binding targets of the Teneurin extracellular domain and their biological significance
-н: Crowther, O
Хэвлэсэн: (2022)

Characterisation of the influenza virus matrix protein M1 and its role in oligomerisation
-н: Mohd Kipli, MFH
Хэвлэсэн: (2020)

Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling
-н: Abigail Brewer, зэрэг
Хэвлэсэн: (2024-08-01)

Construction and characterisation of a siclopps cyclic peptide library.
-н: Koh, Ethel Rui Li.
Хэвлэсэн: (2010)

Structural and functional characterisation of the fungal plasma membrane proton pump, Pma1, and related P-Type ATPases
-н: Geurts, MMG
Хэвлэсэн: (2022)

Tryptophan-dependent membrane interaction and heteromerization with the internal fusion peptide by the membrane proximal external region of SARS-CoV spike protein
-н: Liao, Ying, зэрэг
Хэвлэсэн: (2015)

A novel co-target of ACY1 governing plasma membrane translocation of SphK1 contributes to inflammatory and neuropathic pain
-н: Baowen Liu, зэрэг
Хэвлэсэн: (2023-06-01)

Memprotmd: adding the grease to membrane protein structures
-н: Stansfeld, P, зэрэг
Хэвлэсэн: (2012)

Fundamentals of biochemical calculations /
-н: 410239 Moorthy, Krish
Хэвлэсэн: (2008)

Methods of biochemical analysis/
-н: Glick, David
Хэвлэсэн: (1954)

Protocol to identify multiple protein targets and therapeutic compounds using an in silico polypharmacological approach
-н: Akshaya Simha N, зэрэг
Хэвлэсэн: (2023-09-01)

Characterisation of novel metabolically-stable peptides from chenopodium quinoa
-н: Ng, Jaclyn Cheah Yee
Хэвлэсэн: (2018)

Characterisation of Kindlin-3 and RACK1 interaction in integrin signaling.
-н: Lee, Huishan.
Хэвлэсэн: (2011)

Biochemical and structural studies on the molecular interaction between P53 transcriptional activation domain and anti-apoptotic protein BCL-XL
-н: Xu, Huibin
Хэвлэсэн: (2009)