Towards a structural understanding of drug and peptide transport within the proton-dependent oligopeptide transporter (POT) family.

Towards a structural understanding of drug and peptide transport within the proton-dependent oligopeptide transporter (POT) family.

One of the principal aims of modern drug design is the targeted delivery of drugs within the body, such as to the central nervous system, combined with their exclusion from the liver and kidneys, which break down foreign molecules and subsequently eliminate them. Many of the commonly prescribed drug...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoir:	Newstead, S
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	2011

Míreanna comhchosúla

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Alternating access mechanism in the POT family of oligopeptide transporters.
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Alternating access mechanism in the POT family of oligopeptide transporters
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Accurate Prediction of Ligand Affinities for a Proton-Dependent Oligopeptide Transporter
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Proton movement and coupling in the POT family of peptide transporters
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Energetics of substrate transport in proton-dependent oligopeptide transporters
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Thermodynamic evidence for a dual transport mechanism in a POT peptide transporter
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Molecular Dynamics Simulations Reveal the Proton:Peptide Coupling Mechanism in the Bacterial Proton-Coupled Oligopeptide Transporter YbgH
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Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2.
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Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2
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Structural basis for proton coupled cystine transport by cystinosin
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Two mechanisms of membrane digestion: enzymatic-transport ensemble exists for oligopeptides as well
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An oligopeptide transporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages.
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