Detection of residue contacts in a protein folding intermediate.
Protein folding can be described in terms of the development of specific contacts between residues as a highly disordered polypeptide chain converts into the native state. Here we describe an NMR based strategy designed to detect such contacts by observation of nuclear Overhauser effects (NOEs). Exp...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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