Site-specific hydrogen exchange of proteins: insights into the structures of amyloidogenic intermediates.
We describe the use of nano-electrospray ionization (nano-ESI) mass spectrometry (MS) for monitoring hydrogen exchange. Using this approach, we have compared the fluctuations in structure of the wild-type human lysozyme with those of the Asp67His and Ile56Thr variants, the two amyloidogenic forms of...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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