Site-specific hydrogen exchange of proteins: insights into the structures of amyloidogenic intermediates.

Site-specific hydrogen exchange of proteins: insights into the structures of amyloidogenic intermediates.

We describe the use of nano-electrospray ionization (nano-ESI) mass spectrometry (MS) for monitoring hydrogen exchange. Using this approach, we have compared the fluctuations in structure of the wild-type human lysozyme with those of the Asp67His and Ile56Thr variants, the two amyloidogenic forms of...

ver descrição completa

Detalhes bibliográficos
Principais autores:	Yao, Z, Tito, P, Robinson, C
Formato:	Journal article
Idioma:	English
Publicado em:	2005

Registros relacionados

Probing conformations of amyloidogenic proteins by hydrogen exchange and mass spectrometry.
por: Nettleton, E, et al.
Publicado em: (1999)

Structural Insight of Amyloidogenic Intermediates of Human Insulin
por: Sandip Dolui, et al.
Publicado em: (2018-02-01)

The solution dynamics of amyloidogenic Asp67His variant of human lysozyme: Insights from hydrogen exchange
por: Canet, D, et al.
Publicado em: (2000)

Dissecting the hydrogen exchange properties of insulin under amyloid fibril forming conditions: a site-specific investigation by mass spectrometry.
por: Tito, P, et al.
Publicado em: (2000)

Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme.
por: Canet, D, et al.
Publicado em: (2002)

Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry.
por: Nettleton, E, et al.
Publicado em: (1998)

Misfolding of Amyloidogenic Proteins and Their Interactions with Membranes
por: Annalisa Relini, et al.
Publicado em: (2013-12-01)

Amyloidogenic Intrinsically Disordered Proteins: New Insights into Their Self-Assembly and Their Interaction with Membranes
por: Federica Scollo, et al.
Publicado em: (2020-08-01)

Prediction of amyloidogenic and disordered regions in protein chains.
por: Oxana V Galzitskaya, et al.
Publicado em: (2006-12-01)

A simulated intermediate state for folding and aggregation provides insights into ΔN6 β2-microglobulin amyloidogenic behavior.
por: Sílvia G Estácio, et al.
Publicado em: (2014-05-01)

Is lysozyme variant Thr70Asn amyloidogenic?
por: Booth, DR, et al.
Publicado em: (2001)

Unveiling the Effects of Copper Ions in the Aggregation of Amyloidogenic Proteins
por: Valentina Oliveri
Publicado em: (2023-09-01)

Sequence complexity of amyloidogenic regions in intrinsically disordered human proteins.
por: Swagata Das, et al.
Publicado em: (2014-01-01)

Exploring Proteins Containing Amyloidogenic Regions in the Proteomes of Bacteria of the Order
por: Kirill S Antonets, et al.
Publicado em: (2018-04-01)

Fluorescence Phenomena in Amyloid and Amyloidogenic Bionanostructures
por: B. Apter, et al.
Publicado em: (2020-08-01)

Structural analysis of peptide-analogues of human Zona Pellucida ZP1 protein with amyloidogenic properties: insights into mammalian Zona Pellucida formation.
por: Nikolaos N Louros, et al.
Publicado em: (2013-01-01)

Amyloidogenicity assessment of transthyretin gene variants
por: Nicolai B. Grether, et al.
Publicado em: (2022-08-01)

Characterization of the structure and dynamics of amyloidogenic variants of human lysozyme by NMR spectroscopy.
por: Chamberlain, A, et al.
Publicado em: (2001)

Surface-Directed Structural Transition of Amyloidogenic Aggregates and the Resulting Neurotoxicity
por: Hao Chen, et al.
Publicado em: (2020-02-01)

Structures of a sperm-specific sodium-hydrogen exchanger
por: Hongyuan Qu, et al.
Publicado em: (2024-08-01)

Controversial Properties of Amyloidogenic Proteins and Peptides: New Data in the COVID Era
por: Andrei Surguchov, et al.
Publicado em: (2023-04-01)

Exploring cryptic amyloidogenic regions in prion-like proteins from plants
por: Carlos Pintado-Grima, et al.
Publicado em: (2023-01-01)

Cryptic amyloidogenic regions in intrinsically disordered proteins: Function and disease association
por: Jaime Santos, et al.
Publicado em: (2021-01-01)

Structural similarities and differences between amyloidogenic and non-amyloidogenic islet amyloid polypeptide (IAPP) sequences and implications for the dual physiological and pathological activities of these peptides.
por: Chun Wu, et al.
Publicado em: (2013-01-01)

Retromer disruption promotes amyloidogenic APP processing
por: Christopher P. Sullivan, et al.
Publicado em: (2011-08-01)

Aggregation of an Amyloidogenic Peptide on Gold Surfaces
por: David L. Cheung
Publicado em: (2023-08-01)

Interactions of amyloidogenic proteins with mitochondrial protein import machinery in aging-related neurodegenerative diseases
por: Ashley L. Reed, et al.
Publicado em: (2023-11-01)

Oxidative refolding of amyloidogenic variants of human lysozyme.
por: Wain, R, et al.
Publicado em: (2005)

Investigation of non-covalent interactions of amyloidogenic human lysozyme variants and camelid antibodies
por: Caddy, G, et al.
Publicado em: (2002)

Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry.
por: Yao, Z, et al.
Publicado em: (2006)

Natural and Synthetic Derivatives of Hydroxycinnamic Acid Modulating the Pathological Transformation of Amyloidogenic Proteins
por: Vladimir I. Muronetz, et al.
Publicado em: (2020-10-01)

Development of fluorophores for the detection of oligomeric aggregates of amyloidogenic proteins found in neurodegenerative diseases
por: Kristine L. Teppang, et al.
Publicado em: (2023-12-01)

Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes
por: Taniya Bhardwaj, et al.
Publicado em: (2023-02-01)

CARs-DB: A Database of Cryptic Amyloidogenic Regions in Intrinsically Disordered Proteins
por: Carlos Pintado-Grima, et al.
Publicado em: (2022-05-01)

Looking Beyond the Core: The Role of Flanking Regions in the Aggregation of Amyloidogenic Peptides and Proteins
por: Sabine M. Ulamec, et al.
Publicado em: (2020-12-01)

Exploring Amyloidogenicity of Peptides From Ribosomal S1 Protein to Develop Novel AMPs
por: Oxana V. Galzitskaya, et al.
Publicado em: (2021-08-01)

Amyloidogenic regions and interaction surfaces overlap in globular proteins related to conformational diseases.
por: Virginia Castillo, et al.
Publicado em: (2009-08-01)

Investigation of protein interations between Cks1 and Skp2 using hydrogen exchange nano-electrospray mass spectrometry
por: Yao, Z, et al.
Publicado em: (2004)

Gastrokine-1, an anti-amyloidogenic protein secreted by the stomach, regulates diet-induced obesity
por: Anne-Marie C. Overstreet, et al.
Publicado em: (2021-05-01)

Prediction of parallel in-register amyloidogenic beta-structures In highly beta-rich protein sequences by pairwise propensity analysis
por: Bryan, Allen Wayne
Publicado em: (2010)