Site-specific hydrogen exchange of proteins: insights into the structures of amyloidogenic intermediates.

Site-specific hydrogen exchange of proteins: insights into the structures of amyloidogenic intermediates.

We describe the use of nano-electrospray ionization (nano-ESI) mass spectrometry (MS) for monitoring hydrogen exchange. Using this approach, we have compared the fluctuations in structure of the wild-type human lysozyme with those of the Asp67His and Ile56Thr variants, the two amyloidogenic forms of...

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Autors principals:	Yao, Z, Tito, P, Robinson, C
Format:	Journal article
Idioma:	English
Publicat:	2005

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