Impairment of mitochondrial calcium buffering links mutations in C9orf72 and TARDBP in iPS-derived motor neurons from patients with ALS/FTD

Míreanna comhchosúla

• Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair
  de réir: Ababneh, NA, et al.
  Foilsithe / Cruthaithe: (2020)
• The role of mitochondrial dysfunction and ER stress in TDP-43 and C9ORF72 ALS
  de réir: Dafinca, R, et al.
  Foilsithe / Cruthaithe: (2021)
• Development of LNA gapmer oligonucleotide-based therapy for ALS/FTD caused by the C9orf72 repeat expansion
  de réir: Sathyaprakash, C, et al.
  Foilsithe / Cruthaithe: (2020)
• C9orf72 hexanucleotide expansions are associated with altered ER calcium homeostasis and stress granule formation in iPSC-derived neurons from patients with amyotrophic lateral sclerosis and frontotemporal dementia
  de réir: Dafinca, R, et al.
  Foilsithe / Cruthaithe: (2016)
• Dissecting the contribution of dipeptide repeats to the toxicity in C9orf72 iPSC-derived neurons from ALS/FTD patients
  de réir: Barbagallo, P
  Foilsithe / Cruthaithe: (2021)