Impairment of mitochondrial calcium buffering links mutations in C9orf72 and TARDBP in iPS-derived motor neurons from patients with ALS/FTD

Impairment of mitochondrial calcium buffering links mutations in C9orf72 and TARDBP in iPS-derived motor neurons from patients with ALS/FTD

<div>TDP-43 dysfunction is common to 97% of amyotrophic lateral sclerosis (ALS) cases, including those with mutations in <em>C9orf72</em>. To investigate how <em>C9ORF72</em> mutations drive cellular pathology in ALS and to identify convergent...

書誌詳細
主要な著者:	Dafinca, R, Barbagallo, P, Farrimond, L, Candalija, A, Scaber, J, Ababneh, N, Sathyaprakash, C, Vowles, J, Cowley, S, Talbot, K
フォーマット:	Journal article
言語:	English
出版事項:	Elsevier 2020

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